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Our Pipeline
Evopoint has built an exceptional development pipeline in our core therapeutics areas of interest, particularly oncology and infectious diseases.
Programs Target Indications
Preclinical Phase I Phase II Phase III NDA
XNW4107 BLI HABP/VABP

XNW4107 is a broad spectrum, best-in-class BLI inhibitor of the diazabicyclooctane (DBO) class for all three classes of A/C/D SBL. XNW4107 has successfully completed Phase III registration study in HABP/VABP and is currently at pre-NDA stage.

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XNW3009 hURATI Gout
XNW5004 EZH2 Lymphoma & Solid Tumor

XNW5004 is a best-in-class selective EZH2 inhibitor. In September 2024, XNW5004 was granted BTD (Breakthrough Therapy Designation) by CDE for relapsed or refractory peripheral T-cell lymphoma (PTCL). Pivotal studies in PTCL are ongoing.

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XNW1011¹ BTK Autoimmune
XNW27 ADC Solid Tumors

XNW27 and XNW28 are topoi-based ADCs built on MediLink Therapeutics' platform. Both programs are currently in Phase I/II studies, with superior efficacy and safety observed across a broad range of solid tumors.

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XNW28 ADC Solid Tumors

XNW27 and XNW28 are topoi-based ADCs built on MediLink Therapeutics' platform. Both programs are currently in Phase I/II studies, with superior efficacy and safety observed across a broad range of solid tumors.

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XNW29 PARG Solid Tumors

XNW29 is a first-in-class PARG inhibitor entering Phase I clinical study. In preclinical studies, XNW29 has demonstrated robust efficacy, excellent PK properties and good safety profile.

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XNW34 Degrader Solid tumors

XNW34 is a novel heterobifunctional degrader discovered through our TPD platform. The lead asset is currently in IND-enabling studies, with high oral bioavailability, outstanding in vivo efficacy, and manageable AE profile observed in preclinical studies

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Programs Target Indications
XNW4107 BLI HABP/VABP
Preclinical Phase I Phase II Phase III NDA

XNW4107 is a broad spectrum, best-in-class BLI inhibitor of the diazabicyclooctane (DBO) class for all three classes of A/C/D SBL. XNW4107 has successfully completed Phase III registration study in HABP/VABP and is currently at pre-NDA stage.

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Programs Target Indications
XNW3009 hURATI Gout
Preclinical Phase I Phase II Phase III NDA
Programs Target Indications
XNW5004 EZH2 Lymphoma & Solid Tumor
Preclinical Phase I Phase II Phase III NDA

XNW5004 is a best-in-class selective EZH2 inhibitor. In September 2024, XNW5004 was granted BTD (Breakthrough Therapy Designation) by CDE for relapsed or refractory peripheral T-cell lymphoma (PTCL). Pivotal studies in PTCL are ongoing.

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Programs Target Indications
XNW1011¹ BTK Autoimmune
Preclinical Phase I Phase II Phase III NDA
Programs Target Indications
XNW27 ADC Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW27 and XNW28 are topoi-based ADCs built on MediLink Therapeutics' platform. Both programs are currently in Phase I/II studies, with superior efficacy and safety observed across a broad range of solid tumors.

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Programs Target Indications
XNW28 ADC Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW27 and XNW28 are topoi-based ADCs built on MediLink Therapeutics' platform. Both programs are currently in Phase I/II studies, with superior efficacy and safety observed across a broad range of solid tumors.

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Programs Target Indications
XNW29 PARG Solid Tumors
Preclinical Phase I Phase II Phase III NDA

XNW29 is a first-in-class PARG inhibitor entering Phase I clinical study. In preclinical studies, XNW29 has demonstrated robust efficacy, excellent PK properties and good safety profile.

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Programs Target Indications
XNW34 Degrader Solid tumors
Preclinical Phase I Phase II Phase III NDA

XNW34 is a novel heterobifunctional degrader discovered through our TPD platform. The lead asset is currently in IND-enabling studies, with high oral bioavailability, outstanding in vivo efficacy, and manageable AE profile observed in preclinical studies

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1: XNW1011 is being developed by our partner Everest Medicines in renal indications